ESG vs GLP-1
Almost double the weight loss — in one procedure, with no lifelong drug.
- Real-world weight loss ~20% ~11%
- Format Single procedure, 60 min Weekly injection or daily pills, forever
- Durability 10+ years Weight returns when stopping
- Cost over 5 years $12,995 $18–30K
Sources & notes (3)
- Abu Dayyeh BK, et al. Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity (MERIT). Lancet. 2022;400(10355):441–51.
- Gleason PP, et al. Real-world persistence and adherence to GLP-1 receptor agonists for weight loss. JAMA Netw Open. 2022;5(4):e228081. — Real-world 1-year mean TBWL ≈11%.
- Wilding JPH, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide. Diabetes Obes Metab. 2022;24(8):1553–64. (STEP-1 extension)
Weight-loss figures are mean total-body-weight loss (TBWL) reported in the cited peer-reviewed studies. Individual results vary with starting weight, adherence and the year of concierge care that follows the procedure.







